Prof. Guangyu Zhu Keynote

Location: 

Hudson Beare Building Classroom 4

Date: 

Friday, August 31, 2018 - 13:00 to 14:00

Functionalization and targeted delivery of Pt(IV) anticancer prodrugs

Despite the broad clinical applications of platinum-based anticancer drugs including cisplatin, their side-effects and resistance issues have encouraged researchers to look for novel metal-based anticancer complexes. Non-traditional platinum compounds have been extensively studied and they hold the promise to be further developed as the next-generation platinum drugs. On the other hand, using nanomaterials to deliver cisplatin specifically into cancer cells has proven to be promising to increase the anticancer efficacy of cisplatin and has been a hot topic in the recent years. In this presentation, I will summarize the recent progress in my laboratory in 1) the design, synthesis, and biological evaluation of dual-targeting non-traditional platinum anticancer agents to promote apoptosis or inhibit DNA repair;[1-3] 2) the application of low-cytotoxic and effective drug delivery systems to deliver platinum compounds along with other small-molecules specifically into tumors to increase their antitumor activity.[4-5]

References

1. Ma, L., Ma, R., Wang, Y., Zhu, X., Zhang, J., Chan, H. C., Chen, X., Zhang, W., Chiu, S.-K., and Zhu, G.* (2015) Chem. Commun. 51, 6301-6304 [Back Cover Article]

2. Wang, Z., Xu, Z., and Zhu, G.* (2016) Angew. Chem. Intl. Ed. 55, 15564–15568 [VIP paper and Back Cover Article]

3. Ma, L., Wang, N., Ma, R., Li, C., Xu, Z., Tse, M.-K., and Zhu, G.* (2018Angew. Chem. Int. Ed. 57, 9098-9102

4. Ma, R., Wang, Z., Yan, L., Chen, X.*, and Zhu, G.* (2014J. Mater. Chem. B 2, 4868-4875

5. Wang, N., Wang, Z., Xu, Z., Chen, X., and Zhu, G.* (2018Angew. Chem. Int. Ed. 57, 3426-3430

Bio:

Prof. Guangyu Zhu obtained his B.Sc. in Chemistry from Peking University (2002), where he developed a strong passion for biological chemistry and drug discovery. He moved to the United States and obtained a Ph.D. in Biological Chemistry from the Department of Chemistry at the University of Pittsburgh (2007), where he was working on anticancer drug development and discovery. He subsequently did his postdoc at Massachusetts Institute of Technology (MIT) with Prof. Stephen J. Lippard working on the mechanism of action of cisplatin, one of the most widely used chemotherapeutic drugs in the clinic. He joined the City University of Hong Kong in 2011 and now he is an Associate Professor. Prof. Zhu's research interest lies at the interface of chemistry and biology, focusing on anticancer drug development and mechanism. His current research projects include synthesis and biological evaluation of novel metal-based anticancer agents, development of cancer-specific nanomedicine to conquer cisplatin resistance, and screening of biologically active small-molecule anticancer agents and their target validation, by using interdisciplinary approaches and methods in the areas of biological chemistry, medicinal chemistry, molecular biology, and chemical biology.

Prof. Guangyu Zhu
Prof. Guangyu Zhu

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