Dr. Menolascina’s laboratory at the University of Edinburgh is looking to recruit a Research Associate to work on the automatic (re)design of synthetic promoters for mammalian cells.
As part of this project, the successful candidate will:
- a) Develop a microfluidics-based platform to perform high-throughput screening of synthetic promoters in mammalian cells in suspension
- b) Liaise with the Edinburgh Genome Foundry to build and automatically model large libraries of synthetic inducible promoters
- c) Combine Machine Learning and Computational Optimisation to predict promoter strength, leakiness etc and automatically optimise promoter design to meet set specifications (e.g. maximise fold induction, minimise response time)
- d) Build a promoter that increases sensitivity and specificity of activation of T cells carrying Chimeric Antigen Receptors
The ideal candidate has a background in engineering/computer science and previous experience with techniques/protocols in cell biology and microscopy. Experience with microfluidic device fabrication is desirable.
This post is full time and fixed term for 36 months.
Salary: £33,199 - £39,609 per annum
Closing Date: Wednesday 24th October 2018 at 5pm (GMT)