My research focuses on the development of miniature bioelectronic interfaces for applications in synthetic biology and biomedical engineering. I lead a highly collaborative and interdisciplinary research group in these areas at the Institute for Integrated Micro and Nano Systems (IMNS) within the School of Engineering.
Recent work developed a miniature implantable oxygen sensor, which has been extensively tested in vivo for its potential use in cancer radiotherapy treatment and for post-operative tissue monitoring. Currently, a UoE/NHS consortium is further developing this sensor with the aim of clinical application.
We also have a strong interest in the technology that supports synthetic biological biosensor systems. Specifically, we are developing an electrochemical platform, designed to enable multi-channel data readouts from cell-free systems.
MSc Sensor and Imaging Systems, University of Glasgow, 2016 (Distinction & Class Prize)
PhD Clinical Neurosciences, University of Cambridge, 2011
BA Natural Sciences, University of Cambridge, 2005
Professional Qualifications and Memberships:
WCSIM (Worshipful Company of Scientific Instrument Makers): Beloe Fellowship, 2018
Biochemical Society: Early Career Member
Microelectronics 2 (ELEE08020): lecturing on microfabrication, assisting at tutorials, and student assessment
MSc Electronics project (PGEE11065) and MSc Sensor and Imaging Systems project (PGEE11135): student supervision
Analogue Mixed Signal Laboratory 3 (ELEE09032): teaching assistant
BioSensors and Instrumentation (PGEE11040), Applications of Sensor & Imaging Systems (PGEE11136), and Edinburgh Summer Schools for Beihang University and University of North Carolina: Research guest lecturer
Microfabrication & packaging
Development of novel microfabrication processes for electrochemical sensors. Recent work has focussed on wafer-level deposition and patterning of Nafion (an ionomeric polymer), and development of robust thin-film Ag/AgCl reference electrodes. Also advanced packaging methods for implantable sensors, and particularly the use of flip-chip technologies on flexible substrates.
Use of microfabricated electrochemical sensors for monitoring biological processes. Interests include amperometry and impedance techniques, analysis of sensor performance, wearable instrumentation, and development of novel interfaces between synthetic biology and electronic instrumentation.
Design and testing of implantable microsystems for biomedical sensing. This research involves collaborations within IMPACT, led by Prof Alan Murray, and in vivo validation in animal models with Mr Mark Potter (NHS), Prof Mervyn Singer (UCL), and Dr Mark Gray and Prof Eddie Clutton (RDVS).